Abstract
Our results suggest that CKs, in particular Interleukin-1 and Tumor Necrosis Factor (TNF)-alpha, are involved in the pathogenesis of some neurological disorders and HIV infection. Infact, we observed an exaggerated spontaneous release of TNF-alpha in patients with migraine without aura. Furthermore, in a broad spectrum of patients with HIV-infection we have also found increased amounts of serum TNF-alfa and IL-1. Interestingly, a strict correlation between plasma lipopolysaccharide (LPS) and IL-1 or TNF-alpha levels seems to exist in both group of patients, thus indicating that LPS could account for the production of CKs in the course of the above diseases.
MeSH terms
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AIDS Dementia Complex / physiopathology
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Cytokines / physiology*
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Endotoxins / blood
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HIV Infections / complications
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HIV Infections / physiopathology
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Humans
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Inflammation / physiopathology
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Interleukin-1 / blood
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Interleukin-1 / physiology
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Migraine Disorders / blood
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Migraine Disorders / chemically induced
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Migraine Disorders / physiopathology
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Nervous System Diseases / physiopathology*
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Opportunistic Infections / complications
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Opportunistic Infections / physiopathology
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Recombinant Proteins / adverse effects
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Tumor Necrosis Factor-alpha / adverse effects
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Tumor Necrosis Factor-alpha / physiology
Substances
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Cytokines
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Endotoxins
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Interleukin-1
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Recombinant Proteins
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Tumor Necrosis Factor-alpha