New diketopiperazine metabolites from the sclerotia of Aspergillus ochraceus

J Nat Prod. 1992 Jul;55(7):931-9. doi: 10.1021/np50085a013.

Abstract

Three new diketopiperazine-containing metabolites 1-3 have been isolated from the sclerotia of Aspergillus ochraceus (NRRL 3519) by chromatography on Sephadex LH-20 and reversed-phase hplc. The structures of these compounds were established using extensive high-field 1D and 2D nmr experiments. All three compounds cause moderate reduction in weight gain in assays against the lepidopteran crop pest Helicoverpa zea.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / analysis
  • Aspergillus / chemistry*
  • Diketopiperazines
  • Molecular Structure
  • Piperazines / chemistry*
  • Piperazines / isolation & purification
  • Piperazines / metabolism

Substances

  • Amino Acids
  • Diketopiperazines
  • Piperazines