Intracerebroventricularly administered pertussis toxin blocks the central vasopressor action of neuropeptide Y(13-36) in the awake unrestrained male rat

Neurosci Lett. 1992 Jun 22;140(2):273-6. doi: 10.1016/0304-3940(92)90119-r.

Abstract

The effects of intracerebroventricular (i.v.t.) injections of pertussis toxin (PTX) (10 micrograms/30 microliters, 48 h) were studied on the cardiovascular actions of i.v.t. administered neuropeptide Y(13-36) (NPY(13-36)) as evaluated in the awake unrestrained male rat. The vasopressor action of NPY(13-36) in the peak dose of 3000 pmol per rat was significantly inhibited by pretreatment by PTX. Pertussis toxin treatment alone significantly reduced the baroreceptor reflex elicited by L-phenylephrine. The results are compatible with the view that G-proteins mediate the central vasopressor actions of NPY(13-36) and thus probably are involved in NPY Y2-receptor transduction in cardiovascular areas of the brainstem.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects*
  • Brain / drug effects
  • Heart / drug effects
  • Heart Rate / drug effects
  • Injections, Intraventricular
  • Male
  • Neuropeptide Y / antagonists & inhibitors*
  • Peptide Fragments / antagonists & inhibitors*
  • Pertussis Toxin*
  • Phenylephrine / pharmacology
  • Pressoreceptors / drug effects
  • Pressoreceptors / physiology
  • Rats
  • Rats, Inbred Strains
  • Reflex / drug effects
  • Specific Pathogen-Free Organisms
  • Virulence Factors, Bordetella / administration & dosage
  • Virulence Factors, Bordetella / pharmacology*

Substances

  • Neuropeptide Y
  • Peptide Fragments
  • Virulence Factors, Bordetella
  • neuropeptide Y (13-36)
  • Phenylephrine
  • Pertussis Toxin