Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs

Eur J Biochem. 1992 Jun 1;206(2):315-21. doi: 10.1111/j.1432-1033.1992.tb16929.x.

Abstract

RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon-independent aminoacylation is sequence-specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl-tRNA synthetases to sequences in the acceptor stems of transfer RNAs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Amino Acyl-tRNA Synthetases / metabolism*
  • Base Sequence
  • Escherichia coli / metabolism
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • RNA, Bacterial / genetics
  • RNA, Bacterial / metabolism*
  • RNA, Transfer / metabolism*
  • Substrate Specificity

Substances

  • RNA, Bacterial
  • RNA, Transfer
  • Amino Acyl-tRNA Synthetases