(2'-5')Oligoadenylate and intracellular immunity against retrovirus infection

Int J Biochem. 1992;24(1):55-63. doi: 10.1016/0020-711x(92)90229-t.

Abstract

1. The double-stranded RNA-dependent 2',5'-oligoadenylate (2-5A) synthetase/ribonuclease L (RNase L) system plays an essential role in the establishment of the antiviral state of a cell exposed to virus infection. 2. Until recently, the application of 2-5A derivatives to reinforce this system seemed to be limited mainly due to the low specificity of RNase L for viral RNA. 3. Two new strategies have been developed which yield a selective antiviral effect of 2-5As at least against human immunodeficiency virus-1 (HIV-1) infection: (i) an "intracellular immunization" approach using 2-5A synthetase cDNA linked to HIV trans-acting response element (TAR) and (ii) inhibition of retroviral reverse transcriptase activity by 2-5A analogues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / metabolism
  • Adenine Nucleotides / pharmacology*
  • Antiviral Agents / pharmacology*
  • HIV / drug effects
  • HIV / enzymology
  • HIV / physiology
  • HIV Long Terminal Repeat
  • Oligoribonucleotides / pharmacology*
  • Retroviridae Infections / immunology*
  • Reverse Transcriptase Inhibitors
  • Virus Replication / drug effects

Substances

  • Adenine Nucleotides
  • Antiviral Agents
  • Oligoribonucleotides
  • Reverse Transcriptase Inhibitors
  • 2',5'-oligoadenylate
  • 2',5'-Oligoadenylate Synthetase