Laser immunotherapy: a novel treatment modality for metastatic tumors

Mol Biotechnol. 2003 Sep;25(1):37-44. doi: 10.1385/MB:25:1:37.

Abstract

Laser immunotherapy is a novel approach for the treatment of metastatic tumors. It combines a selective photothermal laser-tissue interaction for direct tumor destruction and an immunoadjuvant-directed simulation for immune responses. In experiments using a rat metastatic tumor model, laser immunotherapy resulted in the eradication of both treated primary tumors and untreated metastases at remote sites. It also induced anti-tumor resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Chitin / analogs & derivatives*
  • Chitin / chemical synthesis
  • Chitin / pharmacology
  • Chitin / therapeutic use
  • Chitosan*
  • Female
  • Immunotherapy / methods*
  • Indocyanine Green / pharmacology
  • Injections, Intralesional
  • Injections, Subcutaneous
  • Laser Therapy*
  • Mammary Neoplasms, Experimental / mortality
  • Mammary Neoplasms, Experimental / pathology
  • Mammary Neoplasms, Experimental / therapy*
  • Neoplasm Metastasis / therapy*
  • Neoplasm Transplantation
  • Rats
  • Survival Analysis
  • Survival Rate

Substances

  • glycated chitosan
  • Chitin
  • Chitosan
  • Indocyanine Green