Abstract
Leinamycin, an antitumor antibiotic isolated from Streptomyces sp., shows a 1,2-dithiolan-3-one 1-oxide heterocycle that appears to be involved in the biological activity. Several derivatives related to 1,2-dithiolan-3-one 1-oxide have been prepared and their activity as antineoplastic agents have been investigated. The synthesized compounds did not display a significative antitumor or cytotoxic activity in vitro.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Drug Design
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Drug Screening Assays, Antitumor
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Heterocyclic Compounds, 2-Ring / chemical synthesis
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Heterocyclic Compounds, 2-Ring / chemistry*
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Heterocyclic Compounds, 2-Ring / pharmacology
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Humans
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Lactams*
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Macrolides / chemistry*
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Sulfhydryl Compounds / chemistry*
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Sulfhydryl Compounds / pharmacology
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Thiazoles / chemistry*
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Thiones / chemistry*
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, 2-Ring
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Lactams
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Macrolides
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Sulfhydryl Compounds
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Thiazoles
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Thiones
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leinamycin