Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives

Acta Pol Pharm. 2003 Mar-Apr;60(2):133-8.

Abstract

Eleven new derivatives of chelidonine I, obtained by functionalization of the alkaloid hydroxyl group, have been tested for CNS activity in mice exhibiting statistically significant effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Animals
  • Benzophenanthridines
  • Berberine Alkaloids*
  • Central Nervous System / drug effects*
  • Central Nervous System / physiology
  • Drug Evaluation, Preclinical / methods
  • Male
  • Mice
  • Phenanthridines*

Substances

  • Alkaloids
  • Benzophenanthridines
  • Berberine Alkaloids
  • Phenanthridines
  • chelidonine