Alterations in rat alveolar surfactant system induced by treatment with carbicron (O-[(2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate)

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):553-5. doi: 10.1016/0742-8413(92)90180-f.

Abstract

1. Intoxication of rats with carbicron (O-([2-butenoic acid)-N,N-dimethylamide-3-yl]-O,O-dimethylphosphate) induced a reduction of the total phospholipids and phosphatidylcholine in lung alveolar surfactant. 2. The lipid transfer protein activity was inhibited due to carbicron treatment. 3. No alterations were observed in phospholipase A2 activity in the alveolar surfactant of intoxicated animals. The structural order parameter (SDPH) of bilayer liposomes, prepared from surfactant phospholipids of carbicron-treated rats also remained unchanged.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Carrier Proteins / antagonists & inhibitors
  • Carrier Proteins / metabolism
  • Fluorescence Polarization
  • Insecticides / toxicity*
  • Male
  • Organophosphorus Compounds / toxicity*
  • Phospholipases A / drug effects
  • Phospholipases A / metabolism
  • Phospholipases A2
  • Phospholipids / metabolism
  • Pulmonary Alveoli / drug effects*
  • Pulmonary Alveoli / enzymology
  • Pulmonary Alveoli / metabolism
  • Pulmonary Surfactants / drug effects*
  • Pulmonary Surfactants / metabolism
  • Rats
  • Rats, Wistar

Substances

  • Carrier Proteins
  • Insecticides
  • Organophosphorus Compounds
  • Phospholipids
  • Pulmonary Surfactants
  • lipid transfer protein
  • dicrotophos
  • Phospholipases A
  • Phospholipases A2