Detection of squamous cell cancer and pre-cancerous lesions by imaging of tissue autofluorescence in the hamster cheek pouch model

Surg Oncol. 1992 Apr;1(2):183-8. doi: 10.1016/0960-7404(92)90032-g.

Abstract

Early detection of invasive and pre-invasive neoplasms of the aerodigestive tract will ultimately improve the management of patients with these lesions. This paper describes the use of quantitative fluorescence imaging of early squamous cell carcinomas in an animal model. Dysplasia, carcinoma in situ and invasive cancers were imaged exploiting tumour autofluorescence. Mapped biopsies were obtained from areas imaged determining a sensitivity of 100% and specificity of 80%. Autofluorescence imaging is an excellent method of detecting neoplasms of the aerodigestive tract.

Publication types

  • Comparative Study

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Bronchoscopes
  • Carcinoma in Situ / chemically induced
  • Carcinoma in Situ / diagnosis*
  • Carcinoma, Squamous Cell / chemically induced
  • Carcinoma, Squamous Cell / diagnosis*
  • Cheek
  • Cricetinae
  • Diagnosis, Computer-Assisted / instrumentation
  • Disease Models, Animal
  • Fluorescence*
  • Male
  • Mesocricetus
  • Mouth Mucosa / pathology
  • Mouth Neoplasms / chemically induced
  • Mouth Neoplasms / diagnosis*
  • Precancerous Conditions / chemically induced
  • Precancerous Conditions / diagnosis*
  • Sensitivity and Specificity

Substances

  • 9,10-Dimethyl-1,2-benzanthracene