Abstract
The regulation of the latent promoter BC-R2 of Epstein-Barr virus (EBV) was examined using the chloramphenicol acetyl transferase (CAT) gene reporter system. A 5' deletion analysis of BC-R2 promoter sequences has been used to characterize a region, described previously as a transcriptional enhancer in EBV positive cell lines, which can repress the BC-R2 transcriptional activity in EBV negative cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Burkitt Lymphoma
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Cell Line
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Chloramphenicol O-Acetyltransferase / genetics
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Chloramphenicol O-Acetyltransferase / metabolism*
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DNA Replication
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Enhancer Elements, Genetic
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Exons
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Gene Deletion
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Gene Expression Regulation, Viral*
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Herpesvirus 4, Human / genetics*
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Herpesvirus 4, Human / isolation & purification
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Humans
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Plasmids
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Promoter Regions, Genetic*
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Recombinant Fusion Proteins / metabolism
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Transcription, Genetic
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Tumor Cells, Cultured
Substances
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Recombinant Fusion Proteins
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Chloramphenicol O-Acetyltransferase