[Ca2+]i effects of bradykinin B2 receptor activation in PC12 cells

Agents Actions Suppl. 1992:38 ( Pt 2):9-15.

Abstract

In PC12 cells, activation of B2 receptors by bradykinin promotes an elevation of cytosolic Ca2+ by two mechanisms: IP3 mediated release of Ca2+ from intracellular stores and stimulation of multiple Ca2+ influx pathways. Since these events can have different kinetics and spatial localizations they can induce diversified effects in different cell areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / pharmacology
  • Animals
  • Bradykinin / pharmacology*
  • Caffeine / pharmacology
  • Calcium / metabolism*
  • Carbachol / pharmacology
  • Egtazic Acid / pharmacology
  • Kinetics
  • Nerve Growth Factors / pharmacology
  • PC12 Cells
  • Receptors, Bradykinin
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Neurotransmitter / physiology*

Substances

  • Nerve Growth Factors
  • Receptors, Bradykinin
  • Receptors, Neurotransmitter
  • Caffeine
  • Egtazic Acid
  • Adenosine Triphosphate
  • Carbachol
  • Bradykinin
  • Calcium