On the basis of experimental studies and of the results obtained, the authors have applied over the last two years, sclerosis of the gastric mucosa with fresh, sterile solution of hypertonic (66%) glucose in 25 patients with duodenal ulcers and cellular and vagal hyperacidity resistant to medical therapy. Mucosclerosis was associated with gastric drainage in 14 patients with duodenal ulcer complicated by stenosis or hemmorhage. Sclerosis of the gastric mucosa is a physiological intervention because it achieves the sclero-atrophy of the acid-secreting glands and vago-sympatic denervation in the gastric territory, while the storage function of the stomach is maintained. It was not followed by extra-gastric disturbances or antro-pyloric distonia. It is easy to perform from the technical viewpoint and has a high degree of fiability, providing constantly satisfactory clinical, functional and metabolic results. Chemical values of basal secretion have decreased in a constant manner but in 9 patients the values of induced acidity showed inconstant decreases. Gastro-antro-pyloro-duodenal transit was good and all operated patients have gained weight. No diarrhea, dumping or peptic recidives were noted.