This work was carried out on 150 subjects. They were classified into four groups: group I: Bronchogenic pulmonary T. B. (n = 96); group II: Haematogenous T. B. (n = 15); group III: Healed T. B. (n = 16), group IV: Healthy control (n = 23). Insulin tolerance test was done for each subject to assess the hypothalamo-hypophyseal axis. Glucose, ACTH, cortisol, GH, and PRL levels were estimated during fasting and over three hours after insulin administration. In group I and II the patients exhibited higher fasting levels of anti-insulin hormones and they respond greater than normals to insulin-induced hypoglycaemia. This might indicate early affection of the pituitary gland by TB infection, yet insulin-induced hypoglycaemia assured efficient function of the gland. In healed TB patients, no significant changes were obtained in the different hormonal behaviour, whether in the fasting state or after stimulation. This might be explained by improvement of the health condition of the patients, and relief of the stress induced by TB infection.