Abstract
The elusive Mls gene(s) are mouse mammary tumor virus genes. The endogenous cotolerogen involved in the clonal deletion of Tcr V beta 5.1, 5.2, and 11 in H-2E+ mouse strains has been narrowed down to MTV-9. We demonstrate that similar to H-2E alpha molecules, human DQw6 beta chain mediated clonal deletion of Tcr V beta 5.1, 5.2, and 11 also requires the MTV-9 gene product. This shows that human class II molecules can present mouse retroviral antigen. Further, backcross analysis involving [B10.M(DQb) x DBA/1] suggest a second cotolerogen in the B10.M background in the clonal deletion of V beta 5-bearing T cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Viral / immunology*
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Genes, Viral / immunology
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HLA-DQ Antigens / immunology*
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Humans
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Immunity, Cellular / immunology*
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Immunoglobulin Variable Region / immunology*
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Immunosuppressive Agents / immunology
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Mammary Tumor Virus, Mouse / immunology
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Mice
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Mice, Inbred DBA
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Mice, Transgenic / immunology
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Organic Chemicals
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Proviruses / immunology
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Receptors, Antigen, T-Cell, alpha-beta / immunology*
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T-Lymphocytes / immunology*
Substances
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Antigens, Viral
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HLA-DQ Antigens
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HLA-DQ6 antigen
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Immunoglobulin Variable Region
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Immunosuppressive Agents
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Organic Chemicals
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Receptors, Antigen, T-Cell, alpha-beta
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Tolerogen