Immunotherapy in two foals with combined immunodeficiency, resulting in graft versus host reaction

J Am Vet Med Assoc. 1977 Jan 15;170(2):167-75.

Abstract

Immunotherapy was attempted in 2 Arabian foals with combined immunodeficiency. One foal was given a transplant of bone marrow from a selected full sibling, and 1 foal was given a fetal thymus transplant. Both foals died. Genetic evidence was obtained for survival of the transplanted tissues in both cases; however, a graft versus host reaction developed in the foal given the fetal thymus transplant.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens
  • Blood Group Antigens
  • Bone Marrow Cells*
  • Bone Marrow Transplantation*
  • Erythrocytes / immunology
  • Female
  • Graft vs Host Reaction*
  • Horse Diseases / immunology
  • Horse Diseases / pathology
  • Horse Diseases / therapy*
  • Horses
  • Immunologic Deficiency Syndromes / immunology
  • Immunologic Deficiency Syndromes / therapy
  • Immunologic Deficiency Syndromes / veterinary*
  • Immunotherapy / veterinary*
  • Kidney / pathology
  • Leukocyte Count
  • Lymphocyte Activation
  • Skin / pathology
  • Thymus Gland / transplantation*
  • Transplantation, Homologous

Substances

  • Antigens
  • Blood Group Antigens