Abstract
Water-soluble group B vitamins metabolism was studied over the course of streptozotocin-induced diabetes mellitus in rats fed semisynthetic isocaloric diets containing 18 and 50% of protein. A high-protein diet in diabetes mellitus does not influence riboflavin metabolism disordered in this disease but reduced 4-pyridoxyl acid excretion to the level characteristic of healthy animals. The observed trend to an increase of liver nicotinamide coenzymes levels and of 1-methylnicotinamide urinary excretion reflects increased niacin synthesis from the diet protein tryptophan, for niacin level is reduced in diabetes.
MeSH terms
-
Animals
-
Coenzymes / metabolism
-
Diabetes Mellitus, Experimental / metabolism*
-
Dietary Proteins / administration & dosage
-
Dietary Proteins / pharmacology*
-
Liver / enzymology
-
Male
-
Niacin / biosynthesis
-
Niacinamide / analogs & derivatives
-
Niacinamide / metabolism
-
Niacinamide / urine
-
Pyridoxal / analogs & derivatives
-
Pyridoxal / urine
-
Rats
-
Rats, Wistar
-
Riboflavin / metabolism
-
Solubility
-
Tryptophan / pharmacology
-
Vitamin B Complex / metabolism*
-
Water / chemistry
Substances
-
Coenzymes
-
Dietary Proteins
-
Water
-
Vitamin B Complex
-
Niacinamide
-
Niacin
-
Pyridoxal
-
Tryptophan
-
Riboflavin
-
N(1)-methylnicotinamide