Abstract
Recipients of solid organ allografts are known to be at increased risk of developing Epstein-Barr virus-related posttransplant lymphoproliferative diseases. A 28-month-old boy who had received a heterotopic liver transplant presented with lymphadenopathy in the abdomen, multiple nodules in the liver, and bilateral renal infiltration 19 months after transplantation. He was diagnosed with a Burkitt-like lymphoma based on bone marrow examination and the finding that the blastic cells in bone marrow were EBER-1 positive. Cytogenetic analysis of the bone marrow cells showed an MLL-AF4 rearrangement. He was treated with a combined chemotherapy regimen. He has been in continuous complete remission for 15 months now.
MeSH terms
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Biliary Atresia / surgery
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Child, Preschool
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Chromosomes, Human, Pair 11 / genetics
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Chromosomes, Human, Pair 11 / ultrastructure
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Chromosomes, Human, Pair 4 / genetics
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Chromosomes, Human, Pair 4 / ultrastructure
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Disease Transmission, Infectious
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Epstein-Barr Virus Infections* / transmission
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Humans
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Immunosuppressive Agents / adverse effects*
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Liver Transplantation / adverse effects*
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Lymphoma, B-Cell / etiology
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Lymphoma, B-Cell / genetics*
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Lymphoma, B-Cell / virology
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Male
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Myeloid-Lymphoid Leukemia Protein
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Oncogene Proteins, Fusion / analysis
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Oncogene Proteins, Fusion / genetics*
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Translocation, Genetic
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Tumor Virus Infections* / transmission
Substances
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Immunosuppressive Agents
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MLL-AF4 fusion protein, human
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Oncogene Proteins, Fusion
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Myeloid-Lymphoid Leukemia Protein