Beta A4 amyloid protein and its precursor in Alzheimer's disease

A I Bush; K Beyreuther; C L Masters

doi:10.1016/0163-7258(92)90039-3

Beta A4 amyloid protein and its precursor in Alzheimer's disease

Pharmacol Ther. 1992;56(1):97-117. doi: 10.1016/0163-7258(92)90039-3.

Authors

A I Bush¹, K Beyreuther, C L Masters

Affiliation

¹ Department of Pathology, University of Melbourne, Parkville, Australia.

PMID: 1297146
DOI: 10.1016/0163-7258(92)90039-3

Abstract

The beta A4 amyloid protein is now understood to play a pivotal role in the development of Alzheimer's disease. This protein is generated by the abnormal processing of the amyloid protein precursor, a large membrane glycoprotein. Insights into the mechanisms of this abnormal processing will give information relevant to the design of new therapeutic strategies for Alzheimer's disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / genetics
Alzheimer Disease / metabolism*
Amino Acid Sequence
Amyloid beta-Peptides / genetics
Amyloid beta-Peptides / physiology*
Amyloid beta-Protein Precursor / physiology
Animals
Humans
Molecular Sequence Data

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor