Abstract
It was demonstrated that several 5'-phosphonates of 4'-thio-5-ethyl-2'-deoxyuridine possessed antiviral activity in vitro and in the murine model of herpes simplex virus type 1 infection. It was shown that the derivatives after intraabdominal administration penetrated effectively into the brain tissue. The agents provided statistically significant increase of the average life span, lower virus titre in the brain and lower lethality when compared to the control group of the animals. It is emphasized that the derivatives were less toxic than the original compound.
MeSH terms
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Antiviral Agents / toxicity
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Chlorocebus aethiops
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Herpes Simplex / drug therapy*
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Herpes Simplex / virology
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Herpesvirus 1, Human / drug effects*
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Mice
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Organophosphonates / toxicity
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Structure-Activity Relationship
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Thionucleosides / chemistry
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Thionucleosides / physiology*
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Thionucleosides / toxicity
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Toxicity Tests, Acute
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Vero Cells
Substances
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4'-thio-5-ethyl-2'-deoxyuridine
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Antiviral Agents
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Organophosphonates
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Thionucleosides