Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential

Pathology. 2003 Aug;35(4):315-8. doi: 10.1080/0031302031000150524.

Abstract

Aims: To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer.

Methods: Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.

Results: P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).

Conclusions: P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / metabolism*
  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / secondary
  • Adenoma / metabolism
  • Adenoma / pathology
  • Adult
  • Aged
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Colonic Neoplasms / metabolism*
  • Colonic Neoplasms / pathology
  • DNA Topoisomerases, Type II / metabolism*
  • DNA-Binding Proteins
  • Drug Resistance, Multiple / physiology
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Lymph Nodes / metabolism
  • Lymph Nodes / pathology
  • Lymphatic Metastasis / physiopathology
  • Male
  • Middle Aged
  • Multidrug Resistance-Associated Proteins / metabolism*
  • Neoplasm Invasiveness

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • DNA-Binding Proteins
  • Multidrug Resistance-Associated Proteins
  • DNA Topoisomerases, Type II