Abstract
Tissue-specific removal of c-jun from epidermal cells in mice leads to a failure of eyelid fusion during embryogenesis and reveals roles for c-Jun in wound repair and tumorigenesis in adult skin. This has provided a definitive test of the in vivo function of AP-1 signalling and shown that EGF signalling is key to all of c-Jun's roles in the epidermis.
MeSH terms
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Animals
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Epidermal Growth Factor / physiology*
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Epidermis / physiology*
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Epithelium / physiology
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Eyelids / physiology
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Feedback, Physiological / physiology
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Genes, jun / genetics
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Genes, jun / physiology*
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Mice
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Mice, Knockout
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Signal Transduction / physiology*
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Transcription Factor AP-1 / physiology*
Substances
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Transcription Factor AP-1
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Epidermal Growth Factor