Epithelial migration: open your eyes to c-Jun

Curr Biol. 2003 Sep 2;13(17):R678-80. doi: 10.1016/s0960-9822(03)00607-9.

Abstract

Tissue-specific removal of c-jun from epidermal cells in mice leads to a failure of eyelid fusion during embryogenesis and reveals roles for c-Jun in wound repair and tumorigenesis in adult skin. This has provided a definitive test of the in vivo function of AP-1 signalling and shown that EGF signalling is key to all of c-Jun's roles in the epidermis.

Publication types

  • Review

MeSH terms

  • Animals
  • Epidermal Growth Factor / physiology*
  • Epidermis / physiology*
  • Epithelium / physiology
  • Eyelids / physiology
  • Feedback, Physiological / physiology
  • Genes, jun / genetics
  • Genes, jun / physiology*
  • Mice
  • Mice, Knockout
  • Signal Transduction / physiology*
  • Transcription Factor AP-1 / physiology*

Substances

  • Transcription Factor AP-1
  • Epidermal Growth Factor