This study investigated the impact of duration-varying response effects on the generation and execution of duration-varying responses. Participants performed short or long keypresses which produced auditory effects of corresponding duration (short response ->short tone, long response ->long tone) or of noncorresponding duration (short response ->long tone, long response ->short tone). Experiment 1 revealed faster responding with a corresponding than with a noncorresponding Response-Effect (R-E) mapping; that is, a temporal R-E compatibility effect. Additionally, increasing effect duration increased response latencies, whereas it decreased keypress duration. Experiment 2 showed that the influence of temporal R-E compatibility persists even when responses are cued in advance, suggesting that at least part of it originates from response generation processes occurring later than a traditional response selection stage. These findings corroborate and complement effect-based theories of action control which assume that the selection, initiation, and execution of movements is mediated by anticipation of their sensory effects.