A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis

Chem Pharm Bull (Tokyo). 2003 Sep;51(9):1103-5. doi: 10.1248/cpb.51.1103.

Abstract

A new iridoid glycoside, gelsemiol 6'-trans-caffeoyl-1-glucoside (1), was isolated from Verbena littoralis, together with four known phenylethanoid glycosides, acteoside (2), 2'-acetylacteoside (3), jionoside (4), and isoverbascoside (5). Their structures were elucidated by spectral data. Compound 1 showed weak enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12D cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Caffeic Acids / chemistry*
  • Caffeic Acids / pharmacology*
  • Cell Line
  • Chromatography, High Pressure Liquid
  • Drug Synergism
  • Glucosides / chemistry*
  • Glucosides / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Nerve Growth Factor / pharmacology*
  • Neurites / drug effects
  • Neurons / drug effects
  • Neurons / ultrastructure
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Verbena / chemistry*

Substances

  • Caffeic Acids
  • Glucosides
  • gelsemiol 6'-trans-caffeoyl-1-glucoside
  • Nerve Growth Factor