Abstract
A new iridoid glycoside, gelsemiol 6'-trans-caffeoyl-1-glucoside (1), was isolated from Verbena littoralis, together with four known phenylethanoid glycosides, acteoside (2), 2'-acetylacteoside (3), jionoside (4), and isoverbascoside (5). Their structures were elucidated by spectral data. Compound 1 showed weak enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12D cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caffeic Acids / chemistry*
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Caffeic Acids / pharmacology*
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Cell Line
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Chromatography, High Pressure Liquid
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Drug Synergism
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Glucosides / chemistry*
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Glucosides / pharmacology*
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Magnetic Resonance Spectroscopy
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Nerve Growth Factor / pharmacology*
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Neurites / drug effects
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Neurons / drug effects
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Neurons / ultrastructure
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Structure-Activity Relationship
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Verbena / chemistry*
Substances
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Caffeic Acids
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Glucosides
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gelsemiol 6'-trans-caffeoyl-1-glucoside
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Nerve Growth Factor