De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

Mirjana Popsavin; Ljilja Torović; Vesna Kojić; Gordana Bogdanović; Sasa Spaić; Velimir Popsavin

doi:10.1016/s0960-894x(03)00712-1

De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3167-70. doi: 10.1016/s0960-894x(03)00712-1.

Authors

Mirjana Popsavin¹, Ljilja Torović, Vesna Kojić, Gordana Bogdanović, Sasa Spaić, Velimir Popsavin

Affiliation

¹ Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia and Montenegro, Yugoslavia. popsavin@ih.ns.ac.yu

PMID: 12951086
DOI: 10.1016/s0960-894x(03)00712-1

Abstract

A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / toxicity*
Cell Line
Cell Line, Tumor
Glucose / chemical synthesis
Glucose / toxicity
Humans
Ribavirin / analogs & derivatives*
Ribavirin / chemical synthesis*
Ribavirin / toxicity*

Substances

Antineoplastic Agents
Ribavirin
Glucose
tiazofurin