2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation

Syed Raziullah Hussaini; Mark G Moloney

doi:10.1039/b303789d

2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation

Org Biomol Chem. 2003 Jun 7;1(11):1838-41. doi: 10.1039/b303789d.

Authors

Syed Raziullah Hussaini¹, Mark G Moloney

Affiliation

¹ The Department of Chemistry, Dyson Perrins Laboratory, The University of Oxford, South Parks Road, Oxford, OX1 3QY.

PMID: 12945761
DOI: 10.1039/b303789d

Abstract

A direct and versatile route enabling the regio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines by reduction of enamines derived from pyroglutamic acid is reported.