Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth

Phytochemistry. 2003 Sep;64(2):555-9. doi: 10.1016/s0031-9422(03)00299-1.

Abstract

Bioactivity-guided fractionation of the EtOAc extract from leaves of Piper crassinervium yielded three prenylated hydroquinones together with two known flavanones naringenin and sakuranetin. Their structures were determined by means of spectroscopic analysis (NMR, IR, UV and MS) including two-dimensional NMR spectroscopy experiments (1H-1H COSY, HMQC, HMBC and NOESY). The antifungal activity was determined by direct bioautography against Cladosporium cladosporioides and C. sphaerospermum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Cladosporium / drug effects
  • Flavanones / chemistry
  • Flavanones / isolation & purification*
  • Flavanones / pharmacology
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Hydroquinones / chemistry
  • Hydroquinones / isolation & purification*
  • Hydroquinones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Piperaceae / chemistry*
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry

Substances

  • Antifungal Agents
  • Flavanones
  • Flavonoids
  • Hydroquinones
  • Plant Extracts
  • sakuranetin
  • naringenin