Cytosine analogues from substituted acetonitriles via Thorpe condensation

Org Lett. 2003 Sep 4;5(18):3333-5. doi: 10.1021/ol035223j.

Abstract

[reaction: see text] A Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials.

MeSH terms

  • Acetonitriles / chemistry*
  • Acylation
  • Cyclization
  • Cytosine / analogs & derivatives*
  • Ethers / chemistry
  • Isocyanates / chemistry
  • Molecular Structure
  • Pyrimidines / chemistry

Substances

  • Acetonitriles
  • Ethers
  • Isocyanates
  • Pyrimidines
  • Cytosine