Abstract
A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amidohydrolases / chemistry
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Amidohydrolases / immunology*
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Animals
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Cryptococcosis / immunology
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Cryptococcosis / prevention & control
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Cryptococcus neoformans / enzymology*
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Cryptococcus neoformans / immunology*
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Female
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Fungal Proteins / chemistry
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Fungal Proteins / immunology
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Interferon-gamma / biosynthesis
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Interferon-gamma / deficiency
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Interferon-gamma / genetics
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Interleukin-12 / antagonists & inhibitors
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Interleukin-12 / biosynthesis
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Interleukin-2 / biosynthesis
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Lymphocyte Activation
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Mice
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Mice, Inbred BALB C
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Mice, Knockout
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Molecular Weight
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Th1 Cells / immunology*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Fungal Proteins
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Interleukin-2
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Tumor Necrosis Factor-alpha
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Interleukin-12
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Interferon-gamma
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Amidohydrolases
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polysaccharide deacetylase