Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans

Infect Immun. 2003 Sep;71(9):5412-7. doi: 10.1128/IAI.71.9.5412-5417.2003.

Abstract

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / chemistry
  • Amidohydrolases / immunology*
  • Animals
  • Cryptococcosis / immunology
  • Cryptococcosis / prevention & control
  • Cryptococcus neoformans / enzymology*
  • Cryptococcus neoformans / immunology*
  • Female
  • Fungal Proteins / chemistry
  • Fungal Proteins / immunology
  • Interferon-gamma / biosynthesis
  • Interferon-gamma / deficiency
  • Interferon-gamma / genetics
  • Interleukin-12 / antagonists & inhibitors
  • Interleukin-12 / biosynthesis
  • Interleukin-2 / biosynthesis
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Molecular Weight
  • Th1 Cells / immunology*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Fungal Proteins
  • Interleukin-2
  • Tumor Necrosis Factor-alpha
  • Interleukin-12
  • Interferon-gamma
  • Amidohydrolases
  • polysaccharide deacetylase