Abstract
Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various phosphatases in order to establish a basic structure-activity relationship (SAR) of the natural product.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Models, Chemical
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Molecular Structure
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Organophosphates / chemical synthesis*
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Organophosphates / chemistry
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Organophosphates / pharmacology*
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Phosphoprotein Phosphatases / antagonists & inhibitors*
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Phosphoprotein Phosphatases / metabolism
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Protein Phosphatase 2
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Pyrones / pharmacology*
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Organophosphates
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Pyrones
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cytostatin
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Phosphoprotein Phosphatases
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Protein Phosphatase 2