Synthesis and biological evaluation of cytostatin analogues

Chem Commun (Camb). 2003 Aug 7:(15):1872-3.

Abstract

Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various phosphatases in order to establish a basic structure-activity relationship (SAR) of the natural product.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Models, Chemical
  • Molecular Structure
  • Organophosphates / chemical synthesis*
  • Organophosphates / chemistry
  • Organophosphates / pharmacology*
  • Phosphoprotein Phosphatases / antagonists & inhibitors*
  • Phosphoprotein Phosphatases / metabolism
  • Protein Phosphatase 2
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry
  • Pyrones / pharmacology*
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Organophosphates
  • Pyrones
  • cytostatin
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2