A form of presynaptic coincidence detection

Neuron. 2003 Aug 14;39(4):579-81. doi: 10.1016/s0896-6273(03)00503-8.

Abstract

In this issue of Neuron, Sjöström et al. provide evidence for a novel presynaptic mechanism for coincidence detection in induction of timing-dependent LTD. In their scheme, simultaneous activation of presynaptic NMDA receptors and CB1 endocannabinoid receptors induces a long-lasting reduction in presynaptic transmitter release.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Cannabinoid Receptor Modulators
  • Glutamic Acid / metabolism
  • Long-Term Synaptic Depression / physiology*
  • Neuronal Plasticity / physiology*
  • Receptors, Cannabinoid
  • Receptors, Drug / physiology
  • Receptors, N-Methyl-D-Aspartate / physiology
  • Receptors, Presynaptic / physiology*

Substances

  • Cannabinoid Receptor Modulators
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Presynaptic
  • Glutamic Acid