Abstract
In this issue of Neuron, Sjöström et al. provide evidence for a novel presynaptic mechanism for coincidence detection in induction of timing-dependent LTD. In their scheme, simultaneous activation of presynaptic NMDA receptors and CB1 endocannabinoid receptors induces a long-lasting reduction in presynaptic transmitter release.
MeSH terms
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Animals
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Cannabinoid Receptor Modulators
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Glutamic Acid / metabolism
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Long-Term Synaptic Depression / physiology*
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Neuronal Plasticity / physiology*
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Receptors, Cannabinoid
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Receptors, Drug / physiology
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Receptors, N-Methyl-D-Aspartate / physiology
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Receptors, Presynaptic / physiology*
Substances
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Cannabinoid Receptor Modulators
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Receptors, Cannabinoid
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Receptors, Drug
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Receptors, N-Methyl-D-Aspartate
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Receptors, Presynaptic
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Glutamic Acid