Donepezil for anticholinergic drug intoxication: a case report

Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):885-7. doi: 10.1016/s0278-5846(03)00119-2.

Abstract

We present a case of delirium due to amitriptyline overdose, which resolved rapidly following initiation of the cholinesterase inhibitor donepezil. The authors discuss the possibility of cholinesterase inhibitors being an effective choice in the management of anticholinergic drug induced delirium.

Publication types

  • Case Reports

MeSH terms

  • Amitriptyline / adverse effects
  • Cholinergic Antagonists / adverse effects*
  • Delirium / chemically induced
  • Delirium / drug therapy*
  • Donepezil
  • Drug Overdose*
  • Humans
  • Indans / therapeutic use*
  • Male
  • Middle Aged
  • Piperidines / therapeutic use*

Substances

  • Cholinergic Antagonists
  • Indans
  • Piperidines
  • Amitriptyline
  • Donepezil