Abstract
The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles. SR-BI is abundantly expressed in several tissues, including the liver, where its expression is regulated by various mechanisms, including the transcriptional activity of nuclear receptors. The importance of SR-BI in overall HDL cholesterol metabolism and its antiatherogenic activity in vivo has been definitively established by SR-BI gene manipulation in mice. Remarkably, SR-BI/apolipoprotein E double-knockout mice develop complex coronary artery disease, myocardial infarction, and heart failure. Additional studies should help to define the importance of SR-BI in human health and disease.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Arteriosclerosis / metabolism*
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Arteriosclerosis / prevention & control
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Biological Transport
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CD36 Antigens / genetics
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CD36 Antigens / metabolism*
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Carrier Proteins*
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Cells, Cultured
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Cholesterol / metabolism*
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Gene Expression Regulation
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Heart Diseases / genetics
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Heart Diseases / metabolism
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Lipoproteins / metabolism
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Lipoproteins, HDL*
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Liver / metabolism
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Membrane Proteins*
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Mice
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Mice, Knockout
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Protein Binding
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RNA-Binding Proteins*
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Receptors, Immunologic*
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Receptors, Lipoprotein / metabolism*
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Receptors, Scavenger
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Scavenger Receptors, Class B
Substances
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CD36 Antigens
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Carrier Proteins
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Lipoproteins
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Lipoproteins, HDL
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Membrane Proteins
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RNA-Binding Proteins
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Receptors, Immunologic
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Receptors, Lipoprotein
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Receptors, Scavenger
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Scarb1 protein, mouse
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Scavenger Receptors, Class B
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high density lipoprotein receptors
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high density lipoprotein binding protein
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Cholesterol