Tweaking copper hydride (CuH) for synthetic gain. A practical, one-pot conversion of dialkyl ketones to reduced trialkylsilyl ether derivatives

Bruce H Lipshutz; Christopher C Caires; Peter Kuipers; Will Chrisman

doi:10.1021/ol035164+

Tweaking copper hydride (CuH) for synthetic gain. A practical, one-pot conversion of dialkyl ketones to reduced trialkylsilyl ether derivatives

Org Lett. 2003 Aug 21;5(17):3085-8. doi: 10.1021/ol035164+.

Authors

Bruce H Lipshutz¹, Christopher C Caires, Peter Kuipers, Will Chrisman

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. lipschutz@chem.ucsb.edu

PMID: 12916987
DOI: 10.1021/ol035164+

Abstract

[reaction: see text] Variations in the reagents and stoichiometries used to generate CuH in situ, as well as the nature of the ligands present, have led to a very efficient and inexpensive method for effecting hydrosilylations of dialkyl ketones.