Abstract
Aim:
To look for new active constituents from Chinese medicine "Sheng-ma", rhizome of Cimicifuga foetida L.
Methods:
The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction.
Results:
Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8).
Conclusion:
Compound 1 is a new compound, and compounds 2-7 were isolated from this plant for the first time.
MeSH terms
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Caffeic Acids / chemistry
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Caffeic Acids / isolation & purification*
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Cimicifuga / chemistry*
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Coumaric Acids / chemistry
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Coumaric Acids / isolation & purification
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Hydroxybenzoates / chemistry
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Hydroxybenzoates / isolation & purification*
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Molecular Conformation
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Molecular Structure
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Phenylacetates / chemistry
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Phenylacetates / isolation & purification*
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Plants, Medicinal / chemistry*
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Rhizome / chemistry*
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Umbelliferones / chemistry
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Umbelliferones / isolation & purification
Substances
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Caffeic Acids
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Coumaric Acids
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Drugs, Chinese Herbal
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Hydroxybenzoates
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Phenylacetates
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Umbelliferones
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cimicifugic acid
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sinapinic acid
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phenolic acid
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esculetin