Synthesis of 2-(pyrimidin-4-yl)indoles

Chem Pharm Bull (Tokyo). 2003 Aug;51(8):975-7. doi: 10.1248/cpb.51.975.

Abstract

The synthesis of 2-substituted isomers of the meridianins, a familiy of bioactive indole alkaloids isolated from the tunicate Aplidium meridianum, was undertaken. The synthetic route comprises six steps, with a microwave promoted Fischer cyclization as the key reaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Indole Alkaloids / chemical synthesis
  • Indoles / chemical synthesis*
  • Pyrimidines / chemical synthesis*
  • Urochordata

Substances

  • Indole Alkaloids
  • Indoles
  • Pyrimidines
  • pyrimidine