Abstract
Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Aorta / anatomy & histology
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Aorta / drug effects*
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Aorta / metabolism
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Dose-Response Relationship, Drug
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Endothelial Cells / metabolism
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Endothelium, Vascular / cytology
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Endothelium, Vascular / metabolism
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Glycine / chemistry
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Glycine / pharmacology*
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In Vitro Techniques
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Myocytes, Smooth Muscle / cytology
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Myocytes, Smooth Muscle / metabolism
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Nitric Oxide / metabolism
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Norepinephrine / metabolism*
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Peptides / chemistry
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Peptides / pharmacology*
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Proline / chemistry
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Proline / pharmacology*
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Rats
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Vasoconstrictor Agents / metabolism*
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Vasodilator Agents / pharmacology*
Substances
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Peptides
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Vasoconstrictor Agents
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Vasodilator Agents
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Nitric Oxide
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Proline
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Glycine
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Norepinephrine