Effect of glyprolines on norepinephrine tone of isolated rat aortic rings

Bull Exp Biol Med. 2003 Apr;135(4):334-6. doi: 10.1023/a:1024696327745.

Abstract

Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta / anatomy & histology
  • Aorta / drug effects*
  • Aorta / metabolism
  • Dose-Response Relationship, Drug
  • Endothelial Cells / metabolism
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • Glycine / chemistry
  • Glycine / pharmacology*
  • In Vitro Techniques
  • Myocytes, Smooth Muscle / cytology
  • Myocytes, Smooth Muscle / metabolism
  • Nitric Oxide / metabolism
  • Norepinephrine / metabolism*
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Proline / chemistry
  • Proline / pharmacology*
  • Rats
  • Vasoconstrictor Agents / metabolism*
  • Vasodilator Agents / pharmacology*

Substances

  • Peptides
  • Vasoconstrictor Agents
  • Vasodilator Agents
  • Nitric Oxide
  • Proline
  • Glycine
  • Norepinephrine