Clinical applications of computed tomography (CT) angiography have increased with the improved technology of multidetector CT systems. Adequate contrast enhancement and the timing of image acquisition are key elements in producing technically adequate CT angiograms. This review article provides guidelines and protocols for four-, eight- and 16-channel multidetector systems in studies of the thoracoabdominal aorta, aortoiliac, and abdominal visceral vasculature, abdominal and extremity run-off studies, and carotid/cerebral CT angiography.