Operation kinetics of a DNA-based molecular switch

J Nanosci Nanotechnol. 2002 Jun-Aug;2(3-4):383-90. doi: 10.1166/jnn.2002.122.

Abstract

The influence of temperature variation, salt concentration, and pH on the operation kinetics of a simple DNA-based molecular switch is investigated. The device shows robust behavior over a wide range of temperatures, pH, and salt concentrations. In particular, the device operates well under physiological conditions. The experimental data can be qualitatively understood in terms of the influence temperature, salt concentration, and pH have on DNA strand interactions.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computers, Molecular
  • DNA / chemical synthesis
  • DNA / chemistry*
  • DNA / radiation effects
  • Equipment Design
  • Fluorescence Resonance Energy Transfer / methods
  • Hot Temperature
  • Hydrogen-Ion Concentration
  • Kinetics
  • Materials Testing / methods
  • Molecular Motor Proteins / chemical synthesis
  • Molecular Motor Proteins / chemistry*
  • Motion
  • Nanotechnology / instrumentation*
  • Nanotechnology / methods
  • Nucleic Acid Conformation
  • Sensitivity and Specificity
  • Sodium Chloride / chemistry
  • Temperature

Substances

  • Molecular Motor Proteins
  • Sodium Chloride
  • DNA