Abstract
Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.
MeSH terms
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Amino Acid Sequence
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Animals
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Axonal Transport / drug effects
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Axonal Transport / physiology*
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Enzyme Inhibitors / pharmacology*
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Mice
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Neurofilament Proteins / drug effects
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Neurofilament Proteins / metabolism*
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Neurons / drug effects
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Neurons / enzymology*
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Phosphoric Monoester Hydrolases / drug effects*
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Phosphorylation
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Protein Subunits / metabolism
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Sequence Deletion
Substances
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Enzyme Inhibitors
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Neurofilament Proteins
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Protein Subunits
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Phosphoric Monoester Hydrolases