A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis

Recent Results Cancer Res. 2003:164:123-34. doi: 10.1007/978-3-642-55580-0_8.

Abstract

1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.

Publication types

  • Review

MeSH terms

  • Apoptosis Regulatory Proteins
  • Apoptosis*
  • Calcitriol / pharmacology*
  • Cell Division
  • Cell Nucleus / metabolism
  • Gene Expression Regulation*
  • Humans
  • Immediate-Early Proteins / genetics
  • Immediate-Early Proteins / metabolism*
  • Membrane Proteins
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Promoter Regions, Genetic / genetics*
  • Protein Transport
  • Response Elements / genetics
  • Transcription, Genetic

Substances

  • Apoptosis Regulatory Proteins
  • IER3 protein, human
  • Immediate-Early Proteins
  • Membrane Proteins
  • Neoplasm Proteins
  • Calcitriol