The research was conducted on male Wistar rats weighing approximately 200 g. Animals of experimental group I were administered 20% ethyl alcohol for drinking, animals of experimental group II--cephalexin in the dose of 42 mg daily, animals of experimental group III--simultaneously alcohol and cephalexin in the mentioned doses. After 10 days the animals were guillotined and pancreas was taken for research. On paraffin sections 7 mu thick there were carried out H + E stain and PAS reaction aimed at discovering neutral mucopolysaccharides. After administering alcohol there was stated a decrease in the activity of exocrime cells and after administering of cephalexim--an increase in this activity. A simultaneous administration of ethyl alcohol and antibiotic causes trophic changes, which can be noticed as introductory, but at this stage--reversible, degenerative changes.