Histological examination of the retinal ganglion layer in rabbits after experimental administration of the new immunosuppressive medicine--Cladribine

Ann Univ Mariae Curie Sklodowska Med. 2002;57(2):376-80.

Abstract

The experiment was carried out on rabbit females of New Zealand breed weighing about 3 kg. Animals from the experimental group received Cladribine according to the schema of experimental treatment in the hairy cell leukemia and rabbits from the experimental group II--according to the schema of experimental treatment in multiple sclerosis. Specimens of retina were collected for histological examinations in the light microscope. It was revealed that administration of Cladribine in the dose corresponding to the therapeutic dose used in human for the treatment of the hairy cell leukemia and multiple sclerosis does not cause evident morphological changes in retinal ganglion cells on the level of light microscope.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cladribine / adverse effects*
  • Cladribine / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Leukemia, Hairy Cell / drug therapy
  • Multiple Sclerosis / drug therapy
  • Rabbits
  • Reference Values
  • Retinal Degeneration / chemically induced*
  • Retinal Degeneration / pathology*
  • Retinal Ganglion Cells / drug effects*
  • Retinal Ganglion Cells / pathology*

Substances

  • Immunosuppressive Agents
  • Cladribine