Abstract
This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Decision Making, Organizational*
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Environmental Exposure / adverse effects*
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Environmental Exposure / analysis
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Environmental Pollutants / adverse effects*
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European Union
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Expert Systems
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Government Regulation
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Hazardous Substances / adverse effects*
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International Cooperation*
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Quantitative Structure-Activity Relationship*
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Toxicity Tests
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United States
Substances
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Environmental Pollutants
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Hazardous Substances