Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

Environ Health Perspect. 2003 Aug;111(10):1391-401. doi: 10.1289/ehp.5760.

Abstract

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Decision Making, Organizational*
  • Environmental Exposure / adverse effects*
  • Environmental Exposure / analysis
  • Environmental Pollutants / adverse effects*
  • European Union
  • Expert Systems
  • Government Regulation
  • Hazardous Substances / adverse effects*
  • International Cooperation*
  • Quantitative Structure-Activity Relationship*
  • Toxicity Tests
  • United States

Substances

  • Environmental Pollutants
  • Hazardous Substances