Objective: To report the associate medical disorders of the patients with endometrial carcinoma and analyze the medical disorders' effects on the treatment and prognosis.
Method: One hundred and forty-six cases of endometrial carcinoma associated with medical disorders who admitted to our center from July, 1971 to Oct, 2001 were analyzed retrospectively. And the other 161 cases without medical disorders who admitted to our center during the same time were chosen as control.
Results: Among the 146 patients with medical disorders, the ordinary disorders were hypertension in 104 patients (71.2%), diabetes mellitus in 30 patients (20.5%) and coronary heart disease in 29 patients (19.9%). Those patients with medical disorders were elder than the control (P < 0.001). The medical disorders were independent of stage, tumor cell differentiation and pathological classification (P > 0.05). The operation ratio of those patients with medical disorders were less than the control. But there was no significance (P > 0.05). The radiotherapy and chemotherapy ratio of them was significantly higher than the control (P < 0.01). Univariate analysis of the cases followed up showed that the prognosis were independent of the associated medical disorders, such as hypertension, diabetes mellitus and coronary heart disease (P > 0.05). Multivariate analysis showed that the prognosis were related to the stage and tumor cell differentiation affected the prognosis remarkable. But the prognosis was independent of age and associated medical disorders.
Conclusions: The endometrial carcinoma often associates with hypertension, diabetes mellitus, coronary heart disease, and so on. The incidence rate of medical disorders increases with the aging of the patients. The medical disorders might affect the therapy to a certain extent. But they do not affect the prognosis remarkably.