Rapid microwave promoted Sonogashira coupling reactions on solid phase

Máté Erdélyi; Adolf Gogoll

doi:10.1021/jo034284s

Rapid microwave promoted Sonogashira coupling reactions on solid phase

J Org Chem. 2003 Aug 8;68(16):6431-4. doi: 10.1021/jo034284s.

Authors

Máté Erdélyi¹, Adolf Gogoll

Affiliation

¹ Department of Organic Chemistry, Uppsala University, Box 599, 751 24 Uppsala, Sweden.

PMID: 12895082
DOI: 10.1021/jo034284s

Abstract

A microwave-enhanced, rapid, and efficient solid-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15-25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared.