The effect of oil as a dietary component on in vitro dissolution of an acid-labile drug

Pharmazie. 2003 Jul;58(7):502-3.

Abstract

The non-benzodiazepine-like anxiolytic agent deramiclane fumarate (EGIA-3886) was used to demonstrate that the presence of high oil/fat content in dissolution media serves as a barrier against accelerated drug degradation in acidic media.

MeSH terms

  • Anti-Anxiety Agents / chemistry*
  • Calibration
  • Camphanes / chemistry*
  • Dietary Fats, Unsaturated / analysis*
  • Solubility
  • Tablets, Enteric-Coated
  • Time Factors

Substances

  • Anti-Anxiety Agents
  • Camphanes
  • Dietary Fats, Unsaturated
  • Tablets, Enteric-Coated
  • deramciclane