Abstract
4-hydroxy-2-nonenal (HNE) activates a variety of signaling pathways. We have recently evaluated the effect of oxidized fatty acid metabolites on cyclooxygenase-2 (COX-2) induction in rat liver epithelial RL34 cells and found that, among the compounds tested, HNE most dramatically induced COX-2. A p38 mitogen-activated protein kinase (p38 MAPK) pathway has been shown to play a key role in the mechanism of the HNE-induced COX-2 expression. It appears that the HNE-induced activation of p38 MAPK leads to the stabilization of COX-2 mRNA.
MeSH terms
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Aldehydes / metabolism*
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Animals
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Cyclooxygenase 2
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Isoenzymes / genetics
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Isoenzymes / metabolism*
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Liver / metabolism
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Mitogen-Activated Protein Kinases / metabolism
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Prostaglandin-Endoperoxide Synthases / genetics
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Prostaglandin-Endoperoxide Synthases / metabolism*
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RNA, Messenger / metabolism
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Rats
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p38 Mitogen-Activated Protein Kinases
Substances
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Aldehydes
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Isoenzymes
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RNA, Messenger
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases
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4-hydroxy-2-nonenal