Abstract
A cluster of related genes whose products show structural identity with bactericidal permeability-increasing protein (BPI) has been identified in the genomes of both mice (on chromosome 2) and humans (on chromosome 20). Genes in the cluster include those encoding parotid secretory protein (PSP), von Ebner minor salivary gland protein (VEMSGP) and sequences in the PLUNC (palate, lung and nasal epithelium clone) family, among others. This mini-review addresses the tissue-specific expression of these genes in the mouse.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antimicrobial Cationic Peptides
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Blood Proteins / genetics*
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Carrier Proteins / biosynthesis*
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Carrier Proteins / genetics
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Epithelial Cells / metabolism
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Epithelial Cells / physiology
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Glycoproteins / biosynthesis*
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Glycoproteins / genetics
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Humans
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Intestinal Mucosa / metabolism*
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Intestinal Mucosa / physiology
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Lipocalin 1
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Membrane Proteins*
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Mice
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Mouth Mucosa / cytology
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Mouth Mucosa / metabolism*
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Mouth Mucosa / physiology
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Phosphoproteins / biosynthesis*
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Phosphoproteins / genetics
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Respiratory Mucosa / metabolism*
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Respiratory Mucosa / physiology
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Salivary Proteins and Peptides / biosynthesis*
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Salivary Proteins and Peptides / genetics
Substances
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Antimicrobial Cationic Peptides
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BPIFA1 protein, human
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BPIFA2 protein, human
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Blood Proteins
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Bpifa1 protein, mouse
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Bpifa2 protein, mouse
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Carrier Proteins
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Glycoproteins
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LCN1 protein, human
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Lipocalin 1
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Membrane Proteins
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Phosphoproteins
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Salivary Proteins and Peptides
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bactericidal permeability increasing protein