Synthetic and antibacterial studies on some new furanopeptides

Farmaco. 2003 Aug;58(8):569-72. doi: 10.1016/s0014-827x(03)00092-2.

Abstract

A series of new furanopeptides (3) are prepared by the coupling of arylsubstituted furoic acids (1) with amino acid methyl esters, di and tetra-peptide methyl esters using dicyclohexyl carbodiimide (DCC) as coupling agent. Some of the newly synthesized compounds are characterized on the basis of IR, 1H NMR, mass spectral data and elemental analysis. Some of the selected compounds are also tested for their antibacterial properties.

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Bacillus / drug effects
  • Bacillus / genetics
  • Escherichia coli / drug effects
  • Furans / chemistry*
  • Furans / pharmacology*
  • Mass Spectrometry / methods
  • Nuclear Magnetic Resonance, Biomolecular
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Oligopeptides / pharmacology*
  • Pseudomonas aeruginosa / drug effects
  • Spectrophotometry, Infrared
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Infective Agents
  • Furans
  • Oligopeptides